|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Autoimmune Diseases
|
0.160 |
GeneticVariation
|
group |
BEFREE |
The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis.
|
21750679 |
2011 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
In this review, we emphasize receptor signaling complexes and regulation of cytoplasmic signaling steps downstream of TLR given their association with some of the same autoimmune diseases where TNIP1 has been implicated.
|
30402506 |
2018 |
|
Autoimmune Diseases
|
0.160 |
AlteredExpression
|
group |
BEFREE |
Genetic variants in the region of TNFAIP3 interacting protein 1 (TNIP1) are associated with autoimmune disease and reduced TNIP1 gene expression.
|
31804013 |
2019 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
Conversely, stimulation of the pathway may also ameliorate autoimmune diseases in which TNIP1 is a susceptibility gene.
|
27129285 |
2016 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-κB and of IKBKE (IKKε), which is an NF-κB activator.
|
23944604 |
2013 |
|
Autoimmune Diseases
|
0.160 |
GeneticVariation
|
group |
GWASCAT |
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
|
23055271 |
2012 |
|
Autoimmune Diseases
|
0.160 |
GeneticVariation
|
group |
BEFREE |
These data confirmed the influence of TNIP1 on an increased susceptibility to SSc and reinforced this locus as a common autoimmunity risk factor.
|
22896740 |
2013 |
|
Immune System Diseases
|
0.110 |
Biomarker
|
group |
BEFREE |
Although TNIP1 and the TNF-α/NF-κB axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown.
|
31691497 |
2020 |
|
Immune System Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
|
23055271 |
2012 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy.
|
23959881 |
2013 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
These data suggest that N4BP1/CEZANNE or TNIP1 may be candidate targets for immunotherapy in neuroblastoma tumors and should lift NF-κB suppression, thereby triggering increased peptide/MHC1-mediated tumor reactivity to enhance therapeutic T-cell targeting.
|
30213788 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
NAF-1 and mNT are also implicated in a number of other human pathologies including diabetes, neurodegeneration and cardiovascular disease, as well as in development, differentiation and aging.
|
28426722 |
2017 |
|
Esophageal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) in the nuclear assembly factor 1 (NAF1) and TNFAIP3-interacting protein 1 (TNIP1) gene were associated with susceptibility to esophageal cancer in a Chinese Han population.
|
28454086 |
2017 |
|
Hematological Disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Through stratified analysis, TNFAIP3 and ETS1 showed significant associations with multiple SLE subphenotypes (such as malar rash, arthritis, hematologic disorder and antinuclear antibody) while TNIP1 just showed relatively weak association with onset age.
|
22087647 |
2011 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
A20 (<i>TNFAIP3</i>) and ABIN-1 (<i>TNIP1</i>) are candidate susceptibility genes for inflammatory bowel disease and other autoimmune or inflammatory diseases, but it is unclear how these proteins interact in vivo to prevent disease.
|
29930103 |
2018 |
|
Neural Tube Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We identified in two unrelated patients two different variants in TNIP1, a gene not previously involved in NTD whose main role is downregulation of the NF-kB pathway.
|
27125519 |
2016 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
TNIP1 keratinocyte deficiency as reported for some skin diseases may predispose these cells to excessive inflammatory signalling upon exposure to viral or bacterial ligands for TLR.
|
29413846 |
2018 |
|
Hematopoietic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Multiple splicing variants of Naf1/ABIN-1 transcripts and their alterations in hematopoietic tumors.
|
17016622 |
2006 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Functional connectivity studies demonstrate an effect of anxiety and depression on four critical brain networks involved in top-down attentional control (fronto-parietal network; FPN), salience detection and error monitoring (cingulo-opercular network; CON), bottom-up stimulus-driven attention (ventral attention network; VAN), and default mode (default mode network; DMN).
|
27744495 |
2017 |
|
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
To assess the association between four TNIP1 SNPs (rs3792792, rs4958881, rs7708392, rs10036748) and carcinogenesis, we used Sequenom Mass-ARRAY technology to determine the genotypes of 302 gastric carcinoma patients and 300 healthy controls in a Northwest Chinese Han population.
|
27250029 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of these genes, a SNP rs7708392 in TNIP1 was reported to be associated with systemic lupus erythematosus (SLE).
|
29559739 |
2018 |